Scientific program

 

Program overview

Schematic overview (pdf file)

Sunday September 8

8h00-8h50: tutorial courses

9h00-10h45: Cell signaling, ionic channels and receptors

10h45-11h15: Poster session 1 (part 1)

11h15-12h15: Electrophysiology of cochlea and auditory pathways

14h00-16h00: Development and regeneration

16h-16h30: Poster session 1 (part 2)

16h30-17h30: Central and peripheral auditory morphology

Monday September 9

8h00-8h50: tutorial courses

9h00-10h45: Genetic: human hereditary deafness 

11h15-12h15: Otoprotection 

10h45-11h15: Poster session 2 (part 1)

14h00 -16h00: Ototoxicity: apoptosis and cell death (I) 

16h-16h30: Poster session 2 (part 2)

16h30 -17h30: Ototoxicity: apoptosis and cell death (II)

 Tuesday September 10

8h00-8h50: tutorial courses

9h00-9h45: Cochlear fluids 

10h00-10h45: Clinical otorhinolaryngology (I)

11h00-12h15: Clinical otorhinolaryngology (II)

 

Detailed program

Oral presentation abstracts (O1-O61, large pdf file)

Poster abstracts (P1-P41, large pdf file)

Sunday September 8

 

8h00-8h50: tutorial courses
A.F. Ryan: "Transgenic mice for inner ear research"
T.R. Van De Water: "Application of experimental embryology techniques to the study of inner ear development"

 

9h00-10h45: Cell signaling, ionic channels and receptors

9h00

O1

Expression patterns of tight junction membrane proteins, occludin and claudins, in the inner ear
S.-I. Kitajiri, M. Furuse, J. Ito & S. Tsukita 

9h15

O2

Expression of KCNQ1-5 voltage-gated K+ channel genes in rat and guinea pig cochleae
G. Liang, M. Ulfendahl & L. Järlebark 

9h30

O3

Localization of nitric oxide synthase I and iii isoforms in the microdissected human cochlea
M. Stach, B. Schneider, C. Schoefer, B. Pikula, P. Franz & H. Felix 

9h45

O4

Biochemical evidence for the presence of serotonin transporters in the rat cochlea
M.A. Vincente-Torres, D. Dávila, M.V. Bartolomé, F. Carricondo & P. Gil-Loyzaga 

10h00

O5

Thyroid hormone & ion channels
M. Knipper, P. Langer, H. Winter, T. Weber, I. Köpschall, K. Rohbock & U. Zimmermann 

10h15

O6

Reversal of vasospasms of the spiral modiolar artery (SMA): A potential new approach for the treatment of sudden hearing loss
E. Q. Scherer, M. Herzog & P. Wangemann 

10h30

O7

VEGF (Vascular endothelial growth factor) dependent activation of extracellular regulated kinase 1/2 (ERK1/2) in the cochlea of puinea pig
O. Michel, A. Hess, D. Labbé, O. Orzechowska, M. Teranishi & W. Bloch

 

10h45-11h15: Poster session 1 (part1)

Cell signaling, ionic channels and receptors (P1-P8)

P1

Estrogen receptors in the inner ear
Hultcrantz M, Stenberg A E, Simonoska M.

P2

Expression pattern of H3-receptor subtypes in the vestibular nuclei of the rat 
Antti A. Aarnisalo, Adrian Lozada, Kaj Karlstedt and Pertti Panula

P3

Ionic currents of type I spiral ganglion neurones of the guinea pig
Zsolt Szabó, Csaba Harasztosi, Géza Szűcs, Zoltán Rusznák, István Sziklai

P4

An improved procedure for the isolation of spiral ganglion cells of the guinea pig
Csaba Harasztosi, Zsolt Szabó, Zoltán Rusznák, Géza Szűcs, István Sziklai

P5

Control of the lateral wall stiffness by efferent neurotransmitters in the OHCs 
Tamas Jozsef Batta, Gyorgy Panyi, Istvan Sziklai

P6

Arguments for steroidogenesis in the rat cochlea 
Lecain E, Guennoun R, Akwa Y., Tran Ba Huy P

P7

Transcriptional control of the cochlear motor protein 
Thomas Weber, Ulrike Zimmermann, Harald Winter, Hans-Peter Zenner, Marlies Knipper

P8

Potassium channel KCNQ4
Harald Winter, Thomas Weber, Karin Rohbock, Iris Köpschall, Ulrike Zimmermann, Marlies Knipper

 

Development and regeneration (P9-P16) 

P9

Apoptotic hair cell death after transient cochlear ischemia in gerbils 
Masafumi Taniguchi, Nobuhiro Hakuba, Kenichiro Koga, Futoshi Watanabe, Jun Hyodo, Kiyofumi Gyo

P10

Induction of neural cell from the bone marrow cells of Chinchilla
Tatsuo Nakamura, Seijun Fukuda, Yasuhiko Shimizu, Yasushi Naitoh

P11

Epidermal growth factor modulates the differentiation of both hair cell and support cell immunophenotypes in rat otic epithelial clonal line 1005 high density cultures
Ken Kojima, Akiko Tanaka, Kei Tashiro, Juichi Ito, Thomas R. Van De Water

P12

p27 expression in the adult mouse cochleae and its alteration after insults
Tsuyoshi Endo, Takayuki Nakagawa, Tae-Soo Kim, Fukuichiro Iguchi, Ji-Eun Lee, Norihiko Murai, Zenchi Taniguchi, Youyi Dong, Yasushi Naito, Juichi Ito

P13

Transplantation of neural stem cells into the mouse inner ear
Fukuichiro Iguchi, Takayuki Nakagawa, Ichiro Tateya, Tae Soo Kim, Tsuyoshi Endo, Ji Eun Lee, Youyi Dong, Yasushi Naito, Juichi Ito

P14

Ephs and ephrins in the neonatal mouse inner ear
James O. Pickles

P15

Morphological analysis of overproduction of hair cells and Deiters’cells in the E19 rat organ of Corti
Marc Thiry, Brigitte Malgrange, Philippe P. Lefevbre

P16

Development of electrical excitability in the neurons of the rat vestibular nucleus in microexplant culture
Marlčne Genlain, Laurence Ris, Emile Godaux

 

Aging effect in the inner ear (P17-P18) 

P17

Suppression tuning of DPOAEs in the CBA/CaJ mouse strain during postnatal development
MacKenzie A Howard, Michael Syka, Karolina Uttlova, Barden B Stagner, Glen K Martin and Brenda L Lonsbury-Martin.

P18

Oxidative stress in the aged cochlea of C57BL/6 mice
Masa-aki Teranishi, Daniel Labbé, Wilhelm Bloch, Alexander Hess, Olaf Michel

 

Central and peripheral auditory morphology (P19-P20)

P19

Vasodilator-stimulated phosphoprotein in the mouse cochlea
B. Schick, M. Praetorius, M. Eigenthaler, M. Müller, U. Walter, M. Knipper

P20

Prestin-like immunoreactivity in outer hair cells of the mustached bat (Pteronotus parnellii)
Marianne Vater, Thomas Weber, Marlies Knipper

 

11h15-12h15: Electrophysiology of cochlea and auditory pathways 

11h15

O8

Are distortion product otoacoustic emission (DPOAE) responses amplified, after carboplatin treatment?
S. Hatzopoulos, J. Petruccelli , M. Previati & A. Martini 

11h30

O9

Auditory nerve stochasticity and deafness
S. O'Leary & R. Shepherd 

11h45

O10

Dependence of exocytosis at the afferent hair cell synapse on L-type Ca2+ channels
T. Moser & A.Brandt 

12h00

O11

The consequences of passive neural properties for eCAP recordings with the forward-masking paradigm
T. Schrama, J. J. Briaire & J. H.M. Frijns 

 

14h00-16h00: Development and regeneration

14h00

O12

Adenovirus-mediated GDNF prevents progressive inner hair cell loss following transient cochlear ischemia in gerbils
N. Hakuba, M. Taniguchi, T. Maetani, J. Hyodo, Y. Ookouchi, Y. Shimizu & K. Gyo. 

14h15

O13

Transplantation of hair cell precursors, hair cells and stem cells in vitro and in vivo
A. F. Ryan, K. Pak & L. M. Mullen 

14h30

O14

Transplantation of autologous mesenchymal stem cells into the spiral ganglion in gentamicin-treatedchinchillas 
Y. Naito, T. Nakamura, F. Iguchi, K. Fujino, T. Endo, S. Kanemaru, T. Nakagawa, Y. Shimizu & J. Ito 

14h45

O15

Proliferative generation of auditory hair cells in culture
B. Malgrange, S. Belachew, M. Thiry, L. Nguyen, B. Rogister, M.-l. Alvarez, J.-m. Rigo, T. R. Van De Water, G. Moonen & P. P.lefebvre 

15h00

O16

Functions of FGFs during otic vesicle induction
Y. Alvarez, V. Vendrell, L. Zelarayan, M. T. Alonso & T. Schimmang

15h15

O17

FGF signaling regulates pillar cell development in the organ of Corti
K. L. Mueller, B. E. Jacques & M. W. Kelley 

15h30

018

Activity-dependent Expression of different BDNF splice variants in the cochlea
J. Tan, I. Köpschall, K. Rohbock, U. Zimmermann & M. Knipper 

15h45

019

Molecular mechanisms of insulin-like growth factor-1 (IGF-1) action during inner ear development 
I. Varela-Nieto & G. Camarero

 

16h-16h30: Poster session 1 (part 2)

for program, see part 1 (10h45-11h15)

 

16h30-17h30: Central and peripheral auditory morphology

16h30

020

Induction of MHC class II antigens of the inner ear
B. Gloddek, D. Bodmer, D. Brors & A. Ryan 

16h45

021

Cochlear aqueduct flow resistance in the guinea pig, measured with small middle ear pressure changes
H. P. Wit, R. A. Feijen, H. M. Segenhout & F. W. J. Albers 

17h00

022

Cochlear aqueduct flow resistance in the guinea pig depends on (quasi) static middle ear pressure
A. Feijen, H. M. Segenhout, F. A. Albers & H. P. Wit  

17h15

023

Deafness and degeneration of the auditory receptor in two experimental mouse models
M.V. Bartolomé, F. Carricondo, E. del Castillo, M.A. Vicente-Torres & P. Gil-Loyzaga 

17h30

024

Dose-dependant viral vector mediated gene transfer in the cochlea of the mouse in vivo
M. Duan, T. Bordet, Z. Chen, M. Mezzina, A. Kahn & M. Ulfendahl 

 

Monday September 9

 

8h00-8h50: tutorial courses
M.W Kelley: "Cell fate determination in the sensory epithelium of the inner ear"
B. Lonsbury-Martin: "Of mice, rabbits, guinea pigs, and monkeys: Otoacoustic emission measures of cochlear function."

 

9h00-10h45: Genetic: human hereditary deafness 

9h00

O25

Expression of a dominant-negative connexin26 in mice causes disorganization of organ of Corti and non-syndromic deafness
K. Ikeda,T. Kudo, S. Kure, A. Xia, Y. Katori, M. Suzuki, T. Kobayashi, K. Kojima, Y. Suzuki, Y. Aoki & Y. Matsubara. 

9h15

O26

Degeneration pattern of the organ of Corti of Mpv17-negative mice.
A.M. Meyer zum Gottesberge, H. Felix & T Massing 

9h30

O27

Otosclerosis: a review 
K. Van Den Bogaert, C. Faghel & G. Van Camp 

9h45

O28

A combination of mouse and human studies reveals new genes and mutations associated with auditory and vestibular dysfunction
K. B. Avraham, N. Ahituv, Z. Brownstein, R. Hertzano, S. Vreugde, T. Walsh, V. Walsh, M.-C. King, M. Hrabe de Angelis, A. Erven, C. Rhodes, K. P. Steel 

10h00

O29

Beethoven, a mouse model for dominant, progressive hearing loss DFNA36
S. Vreugde, A. Erven, C. J. Kros, W. Marcotti, H. Fuchs, K. Kurima, E. R. Wilcox, T. B. Friedman, A. J. Griffith, R. Balling, M. Hrabé de Angelis, K. P. Steel & K. B. Avraham 

10h15

O30

Mutation and expression analysis of the WFS1-gene which is a frequent cause of autosomal dominant low frequency hearing loss
K. Cryns, S. Thys, L. Van Laer, M. Pfister, K. Flothmann, H. Kremer, W. Reardon, R. J.H. Smith & G. Van Camp 

10h30

O31

The DFNA5 mouse: the first analysis of the phenotype 
L. Van Laer, M. Pfister, S. Thys, L. Umans, L. Serneels, F. Kooy, J.-P. Timmermans, F. Van Leuven & G. Van Camp

 

10h45-11h15:  Poster session 2 (part1)

Genetic: human hereditary deafness (P21-P23) 

P21

Hearing impairment related GJB2 mutations in the Hungarian population
Tímea Tóth, Susan Kupka, Nikolaus Blin, Hans-Peter Zenner, Markus Pfister and István Sziklai

P22

Two new otosclerosis families not linked to known loci or collagen 1 genes
Carole Faghel, Kris Van Den Bogaert, Guy Van Camp

P23

Patients affected with Fabry disease have an increased incidence of progressive hearing loss and sudden deafness: an investigation of 22 hemizygotes.
Pierre Bonfils, Dominique Germain, Paul Avan

P23
bis
Investigating and treating progressive hearing loss associated with lysosomal storage diseases using mouse models
Anne K. Hennig, Mark S. Sands, and Kevin K. Ohlemiller

 

Otoprotection (P24-P28)

P24 Reduction of acoustic trauma by systemic and local magnesium application
Heidemarie Haupt, Fred Scheibe, Ovidiu König
P25 The effect of intracochlear drug administration against the acoustic trauma
Hiroshi Yamashita, Kazuma Sugahara, Hiroaki Shimogori
P26 Long-term effect of intracochlear administration of betamethasone on peripheral vestibular disorder in the guinea pig
Hiroaki Shimogori, Osamu Horiike, Takuo Ikeda, Hiroshi Yamashita
P27 Cochlear sensitivity to temporary threshold shifts is affected by sedation/anaesthesia
Fabrice Giraudet, Kathleen Horner, Yves Cazals
P28 IB1/JIP-1 peptides protect hearing and auditory hair cells from noise and aminoglycoside-induced apoptotic death
Azel Zine, Jin Wang, Christophe Bonny, François de Ribaupierre and Jean-Luc Puel

 

Ototoxicity: apoptosis and cell death (P29-P35)

P29

Hypoxia- and ischemia vulnerability of inner and outer hair cells
Birgit Mazurek, Elisabeth Winter, Heidemarie Haupt, Volker Jahnke, Johann Gross

P30

Acoustic stimulation causes the expression of inducible nitric oxide synthase (iNOS/NOS II) in the vestibule of guinea pigs
Ken-ichi Watanabe, Shunta Inai, Alexander Hess, Olaf Michel and Toshiaki Yagi

P31

Free radical scavenger prevents ototoxicity after transient ischemia of the cochlea in gerbils
Toshiki Maetani, Nobuhiro Hakuba, Masafumi Taniguchi, Jun Hyodo, Yoshitaka Shimizu, Kiyofumi Gyo

P32

A Mouse Model for Rapid Degeneration of Spiral Ganglion Neuron
Tae-Soo Kim, Takayuki Nakagawa, Ji-Eun Lee, Fukuichiro Iguchi, Tsuyoshi Endo, Yasushi Naito, Juichi Ito

P33

Time-course of oto-vestibular toxicity from cisplatin
B. Sergi, A. Ferraresi, D. Troiani, G:B: Azzena, G. Paludetti, M: Maurizi and A.R. Fetoni

P34

Substance P as an antiapoptotic factor for cultured postnatal auditory neurons
François Lallemend, Philippe P. Lefebvre, Jean-Michel Rigo, Ingrid Breuskin, Laurent Nguyen, Thomas R. Van De Water, Gustave Moonen & Brigitte Malgrange

P35

Local therapeutic strategy against cisplatin-induced ototoxicity in guinea pig
Jing Wang, Ruth V. Lloyd Faulconbridge , Ana Fetoni, Matthieu Guitton, Remy Pujol, Jean-Luc Puel

 

Cochlear fluids (P36-P38) 

P36

Local inner ear therapy: A technical approach 
Gerrit Paasche, Timo Stöver, Peter Gibson, Thomas Lenarz

P37

Extracellular potassium concentration-related lateral wall stiffness in outer hair cells
Zsolt Farkas, Tamas J Batta, Istvan Sziklai

P38

Detection of aquaporin 2 in the epithelium of human endolymphatic sac by immunohistochemistry
Vincent Couloigner, Dominique Berrebi, Alexis Bozorg-Grayeli, Françoise Cluzeaud, Olivier Sterkers, Michel Peuchmaur, Evelyne Ferrary

 

Clinical otorhinolaryngology (P39-P41) 

P39

A behavioral animal model for salicylate induced Tinnitus in rats
Lukas Rüttiger, Jürgen Ciuffani, Hans-Peter Zenner, Marlies Knipper

P40

A behavior animal model to study the frequency characteristics of salicylate induced Tinnitus in rats
Jürgen Ciuffani, Lukas Rüttiger, Hans-Peter Zenner, Marlies Knipper

P41

Temporal bone density measurement by CT scan in otosclerosis
A. Bozorg Grayeli, Ch. St. Yrieix , F. Cyna-Gorse, Y. Imauchi, Pascale Lainé, E. Ferrary, O. Sterkers

 

11h15-12h15: Otoprotection 

11h15

O32

Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in guinea pigs
Z. Chen, M. Duan, H. Lee, R. Ruan, M. Ulfendahl  

11h30

O33

Systemic a-MSH treatment can delay ototoxicity caused by local administration of cisplatin
F. L.C. Wolters, S. F.L. Klis, F. P.T. Hamers, J. C.M.J. de Groot, D. M. Prieskorn, J. M. Miller & G. F. Smoorenburg 

11h45

O34

Are perilymphatically administered anti-oxidants effective against cisplatin ototoxicity?
 fS. F.L. Klis, N. L.M. Cappaert, J. Wijbenga & G. F. Smoorenburg 

12h00

O35

Cell therapy for application of neurotrophins into mouse inner ear
T. Nakagawa, F. Iguchi, I. Tateya, T. S. Kim, T. Endo, Y. Naito & J. Ito

 

14h00 -16h00: Ototoxicity: apoptosis and cell death (I)

14h00

O36

Expression of hypoxia inducible factor-1 (HIF-1) in rat cochlea
J. Gross, C. Rheinländer, J. Fuchs, B. Mazurek & T. Kietzmann 

14h15

O37

Time sequence of degeneration pattern in the cochlea during cisplatin treatment: A quantitative study
 M. W.M. van Ruijven, J. C.M.J. de Groot & G. F. Smoorenburg 

14h30

O38

Cisplatin cytotoxicity in organ of Corti-derived immortalized cells
M. Previati, L. Bertolaso, D. Bindini, I. Lanzoni, E. Corbacella, S.Hatzopoulos, S. Capitani & A. Martini

14h45

O39

Pathomechanisms of cisplatin and gentamicin ototoxicity
J. Lautermann, N. Dehne, U. Rauen & H. de Groot

15h00

O40

NF-kB is a rescue pathway in aminoglycoside-induced ototoxicity
H. Jiang, S. Sha & J. Schacht

15h15

O41

Cochlear effects of Hexachlorobenzene, a dioxin-type compound, in male adult rats
S. Hadjab, D. Maurel, M. Lucciano, C. Lopez, Y. Cazals & P. Siaud

15h30

O42

Effects of oxidative stress on mitochondrial function in vitro
H. Staecker & D. Li

15h45

O43

Aspirin Miracle Drug: It can stop your headache but can it prevent cisplatin-induced hearing loss?
T. Van De Water, G. Li, S.-H. Sha & J. Schacht

 

16h-16h30:  Poster session 2 (part2)

for program, see part 1 (10h45-11h15)

 

16h30 -17h30: Ototoxicity: apoptosis and cell death (II)

16h30

O44

Multiple cochlear hair cell death responses to noise
T. M. Nicotera, B. Hu & D. Henderson 

16h45

O45

ROS as a factor in TTS and PTS 
D. Henderson, B. Hu, E. Bielefeld & T. M. Nicotera  

17h00

O46

Extremely rapid induction of hair cell apoptosis by impulse noise exposure in the chinchilla cochlea
B. Hu, W. P. Yang, T. M. Nicotera & D. Henderson 

17h30

O47

The role of the MAPK pathway in oxidative stress-induced apoptosis of auditory sensory cells
T. Van De Water, U. Scarpidis, D. Mmadnani, P. Lefebvre, B. Malgrange & H. Staecker 

 

Tuesday September 10

 

8h00-8h50: tutorial courses
E.W. Rubel: "Cellular and molecular approaches towards understanding hair cell death"
H.Staecker: "Gene therapy"

 

9h00-9h45: Cochlear fluids 

9h00

O48

Endocytosis in the epithelial cells of the endolymphatic sac  
A. Kakigi, T. Okada, T. Takeda, S. Shoichi & S. Takeuchi 

9h15

O49

Otoacoustic emissions reveal intracochlear pressure involvement in patients with fluctuating hearing loss and vertigo
P. Avan, B. Büki, L. Gilain & T. Mom 

9h30

O50

The effects of V2-antagonist (OPC-31260) on experimental endolymphatic hydrops in guinea pigs
T. Takeda, S. Sawada, S. Takeda, H. Kitano, M. Suzuki, A. Kakigi & S. Takeuchi 

9h45

O51

Different types of rat endolymphatic sac mitochondria-rich cells
T. A. Peters, E. L.G.M. Tonnaer, W.Kuijpers, C. W.R.J. Cremers & J. H.A.J. Curfs

 

10h00-10h45: Clinical otorhinolaryngology (I) 

10h00

O52

3D-reconstruction of the vestibular endorgans in pediatric temporal bones
E. Bachor, T. Rother & C. Schröck-Pauli 

10h15

O53

A new concept of tinnitus and its treatment
G. Offutt & B. Franz

10h30

O54

Tinitus suppression therapy (tst) with subthreshold sound stimuli
B. Franz & G. Offutt

 

11h00-12h15: Clinical otorhinolaryngology (II)

11h00

O55

The totally implantable micro drug delivery system – future implications
M. Praetorius, A. Limberger, M. Müller, B. Schick, P. Plinkert & M. Knipper 

11h15

O56

Idiopathic sudden sensorineural hearing loss-Will a national database solve the mystery?
E. Hultcrantz, S. Arlinger & R. Zarenoe 

11h30

O57

Effect of intratympanic gentamicin in vestibular function
 N. Perez & J. Rama 

11h45

O58

Fluid dynamics of ground-based and microgravity caloric tests 
M. Kassemi & J. G. Oas 

12h00

O59

Saccular function testing with VEMP: added value in a clinical setting?
Floris Wuyts, Mieke Hoppenbrouwers, Griet Pauwels, Paul Van de Heyning 

12h15

O60

Pharmaceutical countermeasures for space motion sickness and the effects on the otiliths and canals 
Floris Wuyts, Griet Pauwels, Mieke Hoppenbrouwers, An Boudewyns, Paul Van de Heyning 

12h30

O61

Unilateral otolith function testing. Is the utricular function additive?
Floris Wuyts, Mieke Hoppenbrouwers, Griet Pauwels, Paul Van de Heyning

 


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