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Monday September
17th
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9.25 - 9.30. |
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Welcome and Introduction to the workshop
Jonathan Ashmore
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Session 1:
Cochlear genetics and development
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9.30 - 9.45 |
O1 |
Identification of microRNAs in the Developing Cochlea and Vestibule
Lilach M. Friedman,
Ginat Toren, Takunori Satoh, Ronna Hertzano, Martin Irmler, Johannes
Beckers, Eran Hornstein, Donna M. Fekete, and Karen B. Avraham
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9.45 -10.00: |
O2 |
Mosaic
complementation of the shaker1 allele suggests a novel role for
myosin VIIa in hair cell stereocilia
Agnieszka K. Rzadzinska
and Karen P. Steel
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10.00 -10.15 |
O3 |
Hair
cell differentiation becomes tissue specific by E9.5 in mouse inner
ear
Tatsunori Sakamoto,
Juichi Ito and Raj Ladher
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10.15
-10.30
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O4 |
Calbindin and S100 protein expression in the developing auditory
system in mice.
Buckiova D.
and Syka J
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10.30 -10.45 |
O5 |
Characterization of a spontaneous recessive mutation arising in the
mouse
Tecta gene: A model for DFNB21 hearing loss
Miguel Ángel Moreno-Pelayo,
Richard J. Goodyear, Angeles Mencía, Silvia Modamio-Høybjør, Kevin
Legan, Leticia Olavarrieta, Felipe Moreno, and Guy P Richardson
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10.45 -11.15 |
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BREAK
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Session 2
Hair cells 1: Motility
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11.15 -11.30 |
O6 |
Outer
hair cell somatic rather than hair bundle motility is the basis of
the cochlear amplifier
Marcia Mellado Lagarde, Markus Drexl, Andrei N. Lukashkin and Ian
J. Russell
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11.30 -11.45 |
O7 |
Salicylate and chlorpromazine induce nanoscale curvature changes in
the outer hair cell plasma membrane
Jennifer N. Greeson and Robert M. Raphael
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11.45
-12.00
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O8 |
Frequency Effect on Charge Transfer by Prestin: Insight from an
Electro-Diffusion Model
Sean X. Sun, Matthew S. Chana, George Oster, William E. Brownell,
and Alexander A. Spector
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12.00
-12.15
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O9 |
Prestin's state dependence of anion binding
Santos-Sacchi J
and Song L
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12.15 -13.30 |
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LUNCH
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POSTER SESSION 1
(odd numbers) 13.30-14.30
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Session 3
Hair
Cell Damage and Otoprotection
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14.30
-14.45
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O10 |
Mechanism of Age-Related Hearing Loss
Donald Henderson,
Eric Bielefeld, Guang-di Chen and Wei Ping Yang
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14.45 -15.00 |
O11 |
Otoprotection strategies against Cisplatin induced ototoxicity
Guiscardo Lorito,
Pietro Giordano, Sathiyaseelan Theneshkumar, Alessandro Martini and
Stavros Hatzopoulos
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15.00
-15.15
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O12 |
Styrene
ototoxicity and its protection
Guang-Di Chen,
Chiemi Tanaka,Weiping Yang and Donald Henderson
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15.15
-15.30
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O13 |
TNF-α
exposure initiates apoptosis of auditory hair cells that can be
prevented by dexamethasone: Mechanisms
Thomas R Van De Water,
Scott Haake, Shibing Chen, Christine Dinh, Xiaoyun Nong, Adrien A
Eshraghi, and Thomas J Balkany
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15.30 -16.00
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BREAK
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Session 4
Hair
Cell Damage and Otoprotection 2
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16.00 -16.15 |
O14 |
BDNF
protects against Pseudomonas aeruginosa Exotoxin A -induced hearing
loss
Adnan Lidian,
Leif Nordang, Monika
Stenkvist-Asplund, Birgita Linder and Matti Anniko
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16.15 -16.30 |
O15 |
In the
newborn rat cochlea, HSP70 is upregulated on a transcriptional and
translational level during normoxic and hypoxic culture conditions
Agnieszka J. Szczepek,
Johann Gross and Birgit Mazurek
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16.30
-16.45
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O16 |
Adenosine signalling in the cochlea: an emerging role in
neuroprotection
SM Vlajkovic,
CX Guo, R Gupta, GD Housley and PR Thorne
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16.45 - 17.30 |
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The
EuroHear Lecture:
Regulation of cell division and patterning in the regenerating inner
ear
Mark Warchol |
Tuesday
September 18th
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Session 5
Cochlear mechanics
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9.30 -9.45 |
O17 |
Longitudinal change in the role of organ of Corti mass in cochlear
tuning
Ombeline de La Rochefoucauld
and Elizabeth S. Olson
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9.45
-10.00
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O18 |
Negative damping of the cochlear non-linear mechanical responses
Andrei N. Lukashkin,
Mark N. Walling and Ian J. Russell
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10.00-10.15
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O19 |
Combined electric and acoustic stimulation in the cochlea of the
guinea pig
H. Christiaan Stronks,
Huib Versnel, Vera F. Prijs and Sjaak F.L. Klis
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10.15-10.30
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O20 |
Nonlinearity and origin of the round window recorded cochlear
microphonic potential
Alfred L. Nuttall,
Jiefu Zheng, Yuan Zou, Fangyi Chen and Tianying Ren
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10.30-10.45
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O21 |
Aminoglycoside & Acoustic Ototoxicity in Meriones Unguiculatus
Nneka Eze
and Elizabeth S Olson
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10.45-11.15 |
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BREAK
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Session 6
Cochlear homeostasis
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11.15-11.30
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O22 |
The
dynamic characteristics of human organ of Corti homeostasis as
inferred from post noise-burst OAE level fluctuations
David Kemp
and Oliver Brill
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11.30-11.45
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O23 |
Unitary
permeability of gap junctions channels expressed in HeLa cells
Victor H. Hernandez,
Mario Bortolozzi, Saida Ortolano and Fabio Mammano
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11.45-12.00
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O24 |
Expression of Aquaporins and Vasopressin type 2 receptor in the
lateral wall of the Cochlea and Inner Ear Fluid homeostasis
Takeda T,
Nishioka R, Kakigi A, Nishimura M, Okada T, Takeda S and Taguchi D
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12.00-12.15
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O25 |
Bridging the epithelial membrane barrier: Potassium spatial
buffering by Kir4.1/AQP4
B. Hirt,
C. Gleiser, A. Eckhard1, M. Müller, H. Wolburg and H. Löwenheim
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12.15-12.30
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O26 |
Coordinated control of Cx26 and Cx30 at the regulatory and
functional level in the outer sulcus region
Saida Ortolano,
Giovanni Di Pasquale, Giulia Crispino , Fabio Mammano, and John A.
Chiorini
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12.30-13.45 |
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LUNCH
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13.45-14.45 |
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POSTERS 2 (even numbers)
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Session 7
Mitochondria
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14:45
-15:00
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O27 |
Normal
outer hair cell function contrasts with impaired function of
auditory neurons in Friedreich ataxia due to faulty mitochondria
Fabrice Giraudet,
Alain Martelli, Hélène Puccio, Odile Boespflug-Tanguy, Thierry Mom
and Paul Avan
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15.00-15:15
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O28 |
Use of
fluorescent imaging techniques to assess mitochondrial function in
cochlear explants and slices
Zoe F. Mann,
Michael R. Duchen, Daniel J. Jagger and Jonathan E. Gale
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15.15-15.30 |
O29 |
Stress-induced changes in mitochondrial peroxiredoxin in mouse
cochlear hair cells
Fuquan Chen,
Su-Hua Sha and Jochen Schacht
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15.30-16.00 |
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BREAK
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Session 8
Stem Cell Therapies
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16.00-16.15
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O30 |
Synapse
formation between embryonic stem cell-derived neurons and auditory
hair cells in vitro
Masahiro Matsumoto,
Takayuki Nakagawa, Ken Kojima, Tatsunori Sakamoto and Juichi Ito
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16.15-16.30 |
O31 |
Bone
Marrow Derived Cells in Inner Ear Repair
Brian T Tan and Runsheng Ruan
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16.30-16.45 |
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IEB Business Meeting
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19:00 - 22.30 |
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Conference Dinner
The
UnderGlobe,
Shakespeare Globe Theatre,
Bankside
London SE1
Reception 19:00
Guided
tours of the theatre 18:30 -19:00
Coaches leave for St Paul’s Cathedral at 17:30 from Guilford
Street.
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Wednesday September 19th
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Session 9.
Hair cells 2: Transducer and Synapse
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9.30
-9.45
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O33 |
Transducer Gating in the Drosophila Ear
Joerg T. Albert,
Bjoern Nadrowski and Martin C. Goepfert
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9.45 -10.00
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O34 |
Defects In The Atp2b2 Gene Causing Hereditary Hearing And Balance
Loss In Mice And Humans: A Functional Study Of Normal And Mutated
PMCA2 Pumps
M. Bortolozzi,
R. Ficarella, F. Di Leva, S. Ortolano, S.L. Spiden, A. Lelli, G.E.
Shull, M. Brini, P. Gasparini, KP Steel, E. Carafoli and F. Mammano
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10.00-10.15
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O35 |
Calcium, Calmodulin-dependent Regulation of Inner Hair Cell Calcium
Channels
Lisa Grant
and Paul A. Fuchs
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10.15-10.30
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O36 |
Voltage-Gated Channels and Scaffolding Proteins Define Compartments
in the Vestibular Calyx Ending
Anna Lysakowski,
Sophie Gaboyard, Shilpa Chatlani, Steven D. Price, Ruth Anne Eatock
and Jay M. Goldberg
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10.30-11.00 |
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BREAK
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Session 10
Synapse and Nerve
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11.00-11.15
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O37 |
HCN
Channels Shape the Time Course of Postsynaptic Potentials at the
Inner Hair Cell Afferent Synapse
Eunyoung Yi
and Elisabeth Glowatzki
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11.15-11.30
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O38 |
Instantaneous Rate vs Instantaneous Amplitude curves of Auditory
Nerve Fibres are in close agreement with the transduction in the
cilia of Inner Hair Cells.
J. Wiebe Horst,
JoAnn McGee and Edward Walsh
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11.30-11.45
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O39 |
Tonotopic frequency mapping on the basilar membrane of the
Chinchilla (Chinchilla laniger) measured by labelling auditory nerve
fibres with HRP and biocytine
Jean Smolders,
Silvi Hoidis and Marcus Müller
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11.45-12.00
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O40 |
Neural
and receptor cochlear potentials in auditory neuropathy obtained by
transtympanic electrocochleography (ECochG)
Rosamaria Santarelli,
Arnold Starr, Henry J Michalewski and Edoardo Arslan
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12:00 |
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End of IEB 2007 |
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Posters IEB 2007
(Posters will be displayed on Monday and Tuesday from 9 am all day
with timetabled discussion as indicated in the programme. The order
below does not reflect the order in which the posters will be
displayed. For poster assignments see listing of abstracts, and the
index)
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Effects of defensins on frog semicircular canal: evidence of
interaction between the immune and nervous systems.
Andrianov GN,
Nozdrachev AD and Ryzhova IV
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Interaction between Cochlear Cells and Bone Marrow Cells
Susumu Baba, Hiroshi Iwai, Shinryu Lee, Mariko Omae,
Susumu Ikehara, Toshio Yamashita
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Evidence for K+ recycling in an organotypic model of mouse utricle.
S. Bartolami,
M. Cavalier, Z. Ouaray and Ch. Chabbert
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Age-related changes in the cochlear nucleus of C57BL/6J mouse.
Maria Visitación Bartolome.
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Actin dynamics in avian sensory epithelia.
Jonathan Bird1,2,
Nicolas Daudet2 & Jonathan Gale1,2.
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All-or-none delayed spike burst elicited by synaptic activation of
unipolar brush cells in the vestibulo-cerebellum
Luisa Bottà,
Sergio Masetto, Gianpiero Zucca and Egidio D’Angelo
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Effects of hypothyroidism and lack of thyroid hormone receptors
alpha and beta on the expression of Cav1.3 and BK
channels
Brandt N,1
Münkner S,1 Braig C,2
Winter H,2 Knipper M,2
Engel J1
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A comparison of the cochlear and vestibular effects of gentamicin
and kanamycin/furosemide co-treatment in guinea pigs
H.G. Bremer,
H. Versnel, J.C.M.J. de Groot, F.W.J. Albers, S.F.L. Klis
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Comparison of GAD levels in the inferior colliculus and auditory
cortex of two rat strains during aging
Burianová Jana,
Ouda Ladislav, Profant Oliver, Syka Josef
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Expression of Histamine Receptors in the Mammal Vestibule
Sophie Gaboyard-Niay, Cécile Travo and Christian Chabbert
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Illuminating the dynamics of the Notch signalling pathway during
inner ear development
Elena Chrysostomou
and Nicolas Daudet
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Modulation of
cell-cell and cell-extracellular matrix interactions during
neuroblast migration
D. Davies
and C. Nobes
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Identifying Target Genes of the Hair Cell POU-Domain Transcription
Factor Brn-3c
Emily Towers,
Chrysostomos Tornari, Jonathan Gale and Sally Dawson
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Expression of glycine receptors and gephyrin in the rat cochlea
Julia Dlugaiczyk1, Wibke Singer3, Bernhard
Schick1, Heinrich Iro1, Kristina Becker2,
Cord-Michael Becker2, Marlies Knipper3
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Src inhibition prevents the initial cochlear damage induced by
cisplatin chemotherapy
Fetoni1 AR,
Paludetti1 G, Hu2 BH, GD Chen2,
Henderson2 D.
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Role of Coenzyme Q10 and his hydrosoluble multicomposite, Coenzyme
Q10 terclatrate, in protection against noise induced hearing loss.
Fetoni AR,
Fiorita A, La Greca C, Rizzo D, Troiani1 D, Paludetti G.
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Hair cell loss in connexin 30 deficient mice is accompanied by
anomalous epithelial repair patterns.
Andrew Forge1,
Regina Nickel1, Ruth Taylor1, Daniel Jagger1,
Shoeb Ahmad2, Wenxue Tang2,
Xi Lin2
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Three-dimensional organisation of cytoskeletal components in the
sensory epithelia of the inner ear.
Andrew Forge1,
Ruth Taylor1,
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A Subtractive Hybridization Strategy to Identify Barhl1 Target Genes
in Sensory Hair Cells
Valentina Gburcik,
Jonathan Gale and Sally Dawson
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Scanning electron microscope imagining as a good supportive method
in cisplatin induced ototoxicity.
Pietro Giordano,
Sathiyaseelan Theneshkumar, Guiscardo Lorito, Alessandro Martini and
Stavros Hatzopoulos.
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Effect of noise exposure on middle latency response amplitudes in
rats.
Grécová J,
Popelář J, Syka J
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Prevention of
Accelerated Presbycusis by Maintenance of Systemic Immune Functions
Hiroshi Iwai,
Susumu Baba, Shinryu Lee, Mariko Omae, Susumu Ikehara, Toshio
Yamashita
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Connexin 30 trafficking to the plasma membrane via a
Golgi-independent pathway
John Kelly,
Regina Nickel, Andrew Forge, Daniel Jagger
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Effects of thyroid hormone deficiency on Ca2+ currents
and exocytosis in cochlear inner hair cells
Stephanie Kuhn1,
Claudia Braig2, Stefan Münkner1, Harald Winter2,
Marlies Knipper2 and Jutta Engel1
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ERK1/2 activation in support cells during hair cell damage is a
common signalling mechanism that may contribute to hair cell death
Manuela Lahne
and Jonathan Gale
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Association of HLA-DRB1*1101 allele with bilateral Meniere´s disease
in mediterranean population
Jose A. Lopez-Escamez1,
Herminio Perez-Garrigues 2 Jose R Vilchez2 ,
Andres Soto-Varela 3, Sofia Santos-Perez 3, ,
Ismael Aran 5, Miguel A. Lopez-Nevot2
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Development of a bioreactor system aiming at the in vitro culture of
the functionally mature Organ of Corti
H. Arnold,
A. Müller, M. Müller, H. Löwenheim
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AQP4 and Kir4.1 are colocalized in distinct supporting cell
populations of the rat cochlea
A. Eckhard1,2,
B. Hirt1,2, C. Gleiser1,2, M. Müller1,
H. Löwenheim1
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Functional analysis of water flow in cochlea supporting cells
C. Gleiser1,2,
B. Hirt1,2,A. Eckhard1, M. Müller1,
H. Löwenheim
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Noise trauma in the guinea pig
M. Müller1,
M. Tisch2, H. Maier2, B. Hirt1, H.
Löwenheim1
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Methodological study for isolation of stem cells from the spiral
ganglion
S. Sandke,
K. Aulwurm, J. Waldhaus, A. Gharabaghi, H. Löwenheim
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Nestin expression in the organ of Corti during embryonic and
postnatal development
J.
Waldhaus1,
H. Winter1, B. Hirt1,2, M.
Müller1, H. Löwenheim1
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Dynamics of Fgf3 expression in the developing mouse inner ear
Androulla Economou,
Stephanie Cadot and Mark Maconochie
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Effect of interference tones on DPOAE level/phase maps in rabbits
GK Martin,1,2
BB Stagner,1 T Fleck,3 PF Fahey,4
BL Lonsbury-Martin1,2
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A computationally based large scale model of potassium flow in the
cochlea
Pavel Mistrík1,
Peter Saffrey1, Chris Mullaley1, Renato Nobili2,
Fabio Mammano2 and Jonathan Ashmore1,3
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Upregulation of erythropoietin and erythropoietin receptor mRNA in
organ of Corti, modiolus and stria vascularis of newborn rats
Mazurek B, Haupt H, Amarjargal N, Machulik A, Moller R,
Ungethüm1 U, Kuban1 RJ, Szczepek, AJ, Gross J
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The role of prestin and the tectorial membrane in the generation of
electrically evoked otoacoustic emissions in mice.
Markus Drexl1,2, Marcia Mellado Lagarde1,
Jian Zuo3, and Ian J. Russell1
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Number, Design and Function of Hair Cell Synapses along the
Tonotopic Axis of the Cochlea
Alexander C. Meyer1, Darina Khimich1,
Alexander Egner2, Youri Yarine3, Tobias Moser1
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Ionic currents through Cav1.3 Ca2+ channels in
mature mouse inner hair cells under mobile phone field exposure
S. Münkner1,
A. El Ouardi2, J. Streckert2, R. Vonthein3,
V. Hansen2, J. Engel1
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Differential modulation of Cav1.3 Ca2+
channels by Ca2+ binding proteins and significance for
auditory hair cell function
Guiying Cui1*, Alexander Meyer2*, Irina
Calin-Jageman1, Jakob Neef2, Françoise
Haeseleer3, Tobias Moser2, and Amy Lee1
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MOLECULAR CORRELATES OF TINNITUS IN THE AUDITORY SYSTEM: BDNF, Arg
3.1, AND THE ROLE OF GABA
Rama Panford-Walsh1, Wibke Singer1, Lukas Rüttiger1, Hyun-Soon
Geisler1, Ulrike Zimmermann1, Iris Köpschall1, Karin Rohbock1, Elmar
Oestreicher2, Helen Haas1 and Marlies Knipper1
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Expression patterns of erythropoietin and erythropoietin receptor in
the spiral ganglion of guinea pig after noise exposure
Jae Yong Park, MD,
Dong-Hyun Kim, MD, Ah Young Kim, MD, and Yong Ho Park, MD, PhD
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Expression patterns of KCNJ10 K+ channel in the cochlear lateral
wall after acoustic trauma
Yong Ho Park, MD, PhD,
Jae Yong Park, MD, and Ah Young Kim, MD
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Presence and Characteristics of Spontaneous Otoacoustic Emissions in
Children and adolescents
Pelánová J
1,2, Groh D 1,2, Popelář J 1,
Kabelka Z 2, Syka J 1.
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Mitotracker staining of mitochondria in outer hair cells of the
guinea pig cochlea
Jim Pickles,
Hema Indrasamy
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Mouse pharmacological models of sensorineural hearing loss.
Poirrier AL,
Kim TS, Vandenbosch R, Nguyen L, Lefebvre PP, Malgrange B.
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Prestin self-association, lateral mobility and membrane cholesterol
Louise E. Organ, Jennifer N. Greeson, and Robert M. Raphael
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Computational Model of Ion Transport in the Stria Vascularis
Imran Quraishi and Robert M. Raphael
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Targeted Disruption of Otoa with EGFP demonstrates otoancorin is
required for adhesion of the tectorial membrane to the spiral limbus.
P. Kevin Legan1,
Lindsey Welstead1, Richard J. Goodyear1,
Christine Petit2 and Guy P. Richardson1
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Studying the distribution of inositol phospholipids in sensory hair
cells with EGFP-tagged reporter constructs
Gowri D. Nayak,
Richard J. Goodyear and Guy P. Richardson
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NO-cGMP pathway and hearing loss
Lukas Rüttiger,
Robert Feil*, Susanne Feil* and Marlies Knipper
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Age-related changes in THE rat auditory system
Natalia Rybalko,
Jana Pelanová, Stanislava Hamsová,
Josef Syka
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Which interstereocilial links can be found in disorganized hair
bundles of cadherin 23 mutants?
Agnieszka K. Rzadzinska,
Karen P. Steel
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IDENTIFICATION OF IGF-I TARGET GENES IMPLICATED IN INNER EAR
DEVELOPMENT AND FUNCTIONAL MATURATION
Hortensia
Sanchez-Calderon1,2,
Lourdes Rodriguez de la Rosa1,
Marta Milo2 Jose R. Pichel3, Matthew Holley2
and Isabel Varela-Nieto1
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Noise stress in a Otoprotective strategy against Cisplatin induced
Ototoxicity
Sathiyaseelan Theneshkumar,
Stavros Hatzopoulos, Guiscardo Lorito, Pietro Giordano, Sara Magosso
, Lucia Bertolaso, Alessandro Martini.
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Relationship between Accelerated Presbycusis and Immunosenescence
Shinryu Lee,
Hiroshi Iwai, Susumu Baba, Mariko Omae, Susumu Ikehara, Toshio
Yamashita
|
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Identification of markers for pathological neuronal plasticity
changes in the auditory system
Singer W,
Rüttiger L, Panford-Walsh R, Reinbothe T, Rohbock K, Knipper M
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Expression and immunolocalization of aquaporin-6 (Aqp6) in the rat
inner ear
Daizo Taguchia,
Taizo Takedab,
Akinobu Kakigib,
Teruhiko Okadac,
Rie Nishiokab,
Hiroya Kitanod
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Effects of Aging on Inner Ear Morphology in Dogs Related to
Brainstem Responses to Pure-Tone Auditory Stimuli
G. ter Haar1,
J.C.M.J. de Groot2, A.J. Venker-van Haagen1,
W.E. van den Brom1, F.J. van Sluijs1 and G.F.
Smoorenburg2
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An atypical cell during development of the auditory organ : the
inner pillar cell.
Nicolas Thelen,
Brigitte Malgrange and Marc Thiry
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Delivery of brain-derived neurotrophic factor to the guinea pig
cochlea using Gelfoam
Versnel H,
Sedee RJ, Agterberg MJH, De Groot JCMJ, Albers FWJ, Klis SFL
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Speech-in-noise intelligibility does not correlate with efferent
olivocochlear reflex in humans with normal hearing
Wolfgang Wagner,
Kathrin Frey, Guido Heppelmann
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Different appearance of apoptosis caused by platinum-derived
anti-cancer drugs in the vestibule of guinea pig
Ken-ichi Watanabe,
Shuta Inai, Ken-Jinnnoiuchi, Hess Alexander, Olaf Michel, Toshiaki
Yagi
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Expression of osmotically responsive cationic channel TRPV4 in the
endolymphatic sac
H. Kumagami,
M. Terakado, Y. Saino, A. Baba, D. Fujiyama, K. Takasaki, H.
Takahashi
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Human Cytomegalovirus and Factors Involved in Neurogenesis
Jane C. Murphy and John H. Sinclair
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Role of Ca2+ binding proteins in hair cell presynaptic
function
Tina Pangršič1,
Nicola Strenzke1,2, Beat Schwaller3, Tobias
Moser1
|
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|
Region-specific transcriptional expression of neurotrophin-family
genes in the cochlea of newborn rat
Gross J, Szczepek, AJ, Amarjargal N, Machulik A, Fuchs J,
Ungethüm1 U, Kuban1 RJ, Haupt H, Mazurek B
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